[Behçet's disease associated with peripheral neuropathy].

Area of Science:

• Neurology
• Rheumatology

Background:

• Behçet's disease is a rare multisystem inflammatory disorder.
• Peripheral nervous system (PNS) involvement is an uncommon manifestation.

Observation:

• A 47-year-old male with a 6-year history of Behçet's disease presented with a 2-year history of neurological symptoms.
• Symptoms included limb paresthesia, weakness, diarrhea, and erectile dysfunction.
• Electromyography and nerve biopsy confirmed axonal sensorimotor neuropathy.

Findings:

• The patient exhibited both sensorimotor and autonomic peripheral neuropathy.
• Standard tests ruled out other common causes and entero-Behçet.
• Treatment with prednisone, cyclophosphamide, and carbamazepine improved paresthesia.

Implications:

• This case highlights the rare association of sensorimotor and autonomic neuropathy in Behçet's disease.
• The underlying mechanism of neuropathy in Behçet's disease remains unclear, possibly involving vasculitis.
• Further research is needed to understand and manage PNS complications in Behçet's disease.