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A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
Published on: July 20, 2022
[Retroperitoneal fibrosis]
1Service de néphrologie et de médecine interne, Hôpital Charles Nicolle, Boulevard du 9 Avril 1938, 1006 BS-Tunis, Tunisia.
Objective:
We studied the clinical, therapeutic and progressive characteristics of retroperitoneal fibrosis.
Methods:
We analysed the observations of retroperitoneal fibrosis diagnosed between 1980 and 2002 in our hospital, from the summaries of 15 patients exhibiting retroperitoneal fibrosis (RPF). Therapeutical supervision was based on biology and radiology.
Results:
There were 11 men and 4 women with a mean age of 44.5 years ranging from 28-64 years. Pain was predominantly lumbar or abdominal in all patients. An inflammatory syndrome was observed in all patients and renal failure in 11. Radiological examinations revealed single or bilateral in 14 cases and the fibrosis plaque in 13 cases. Treatment consisted in corticosteroids alone in 9 patients, surgery alone in 3 cases and surgery with corticosteroids in 3 patients. Ten relapses (range: 1-5) occurred in 4 patients when corticosteroids were stopped. After a mean follow-up of 36 months (range:18 days-11 years), one death was observed, 12 patients had normal renal function and 2 patients had persistent moderate renal failure.
Conclusion:
This study confirms the rarity of retroperitoneal fibrosis, the difficulty in its diagnosis, the frequency of pain, inflammatory syndrome and renal failure. Corticosteroids are efficient and regular follow-up is required.
Insights
Retroperitoneal fibrosis (RPF) is rare and difficult to diagnose, often presenting with pain, inflammation, and kidney issues. Corticosteroids are effective, but ongoing monitoring is essential for managing this condition.
Area of Science:
- Nephrology
- Rheumatology
- Oncology
Context:
- Retroperitoneal fibrosis (RPF) is a rare condition characterized by inflammatory tissue in the retroperitoneum.
- Diagnosis can be challenging, often requiring a combination of clinical, radiological, and biological assessments.
Purpose:
- To investigate the clinical, therapeutic, and progressive characteristics of retroperitoneal fibrosis (RPF).
- To evaluate treatment outcomes and identify factors influencing disease progression.
Summary:
- A retrospective analysis of 15 RPF patients (1980-2002) revealed a median age of 44.5 years, with common symptoms including pain, inflammatory syndrome, and renal failure.
- Treatment involved corticosteroids, surgery, or both. Corticosteroid therapy showed efficacy, though relapses occurred upon cessation. Long-term follow-up indicated good renal recovery in most patients.
Impact:
- This study highlights the importance of early diagnosis and consistent management of RPF.
- It underscores the effectiveness of corticosteroids in managing RPF and the necessity for regular patient follow-up to prevent complications and relapses.