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Updated: Aug 18, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
Rotating-frame intermolecular double-quantum spin-lattice relaxation T1rho, DQC-weighted magnetic resonance imaging
Bingwen Zheng1, Dennis W Hwang, Zhong Chen
1Department of Chemistry, National Taiwan University, and Institute of Atomic and Molecular Science, Academia Sinica, Taipei, Taiwan.
Abstract:
In this study, spin-locking techniques were added as a part of intermolecular multiple-quantum experiments, thereby introducing the concept of rotating-frame intermolecular double-quantum spin-lattice relaxation, T(1rho, DQC). A novel magnetic resonance imaging methodology based on intermolecular multiple-quantum coherences is demonstrated on a 7.05-T microimaging scanner. The results clearly reveal that the intermolecular double-quantum coherence T(1rho, DQC)-weighted imaging technique provides an alternative contrast mechanism to conventional imaging.
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