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High dose radiation induced meningioma
S N Shenoy1, K G Munish, A Raja
1Department of Neurosurgery, Kasturba Medical College and Hospital, Manipal, India. shenoysn@yahoo.com
British Journal of Neurosurgery
|April 1, 2005
Summary
High-dose cranial radiation can cause secondary brain tumors like meningiomas. Patients require lifelong surveillance for radiation-induced tumors after cranial irradiation.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Radiation therapy is crucial for treating intracranial tumors.
- However, radiation exposure is a known risk factor for secondary neoplasms.
Observation:
- This study details three cases of radiation-induced meningiomas post-high-dose cranial irradiation.
- Tumors arose within the prior radiation field, meeting criteria for radiation-induced neoplasms.
- Unique features included atypical meningioma characteristics, multiple tumors, and early recurrence in some cases.
Findings:
- Radiation-induced meningiomas can manifest with aggressive features.
- Younger patients may have a shorter latency period between irradiation and tumor development.
- These tumors can occur years after initial treatment.
Implications:
- Patients receiving cranial irradiation face a lifelong risk of developing secondary meningiomas.
- Long-term clinical and radiological surveillance is essential for early detection.
- Understanding these risks informs patient management and follow-up protocols.