Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relative glomerular hyperfiltration in primary aldosteronism.

Jean Ribstein1, Guilhem Du Cailar, Pierre Fesler

  • 1Department of Medicine, Hôpital Lapeyronie, 34295 Montpellier cedex 5, France. j-ribstein@chu-montpellier.fr

Journal of the American Society of Nephrology : JASN
|April 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Non-pharmacological interventions: A new paradigm and opportunities for internist].

La Revue de medecine interne·2025
Same author

[Non-pharmacological interventions: A new paradigm and opportunities for internists].

La Revue de medecine interne·2025
Same author

Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney.

Blood pressure·2024
Same author

Hypertension and Cardiovascular Outcomes in Inflammatory and Autoimmune Diseases: A Systematic Review and Meta-analysis.

Current hypertension reports·2024
Same author

Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire.

Journal of hypertension·2024
Same author

Association between Elevated Plasma Vitamin B12 and Short-Term Mortality in Elderly Patients Hospitalized in an Internal Medicine Unit.

International journal of clinical practice·2023

Primary aldosteronism (PA) patients exhibit higher urinary protein excretion than essential hypertension (EH) patients. PA treatment reveals relative hyperfiltration, suggesting specific kidney effects beyond blood pressure levels.

Area of Science:

  • Nephrology
  • Endocrinology
  • Hypertension Research

Background:

  • Primary aldosteronism (PA) is linked to cardiovascular issues, but its specific kidney effects are less understood.
  • Investigating kidney function in PA is crucial for comprehensive patient management.

Purpose of the Study:

  • To assess renal function and protein excretion in patients with tumoral primary aldosteronism (PA) compared to essential hypertension (EH).
  • To evaluate the impact of surgical cure or medical treatment on kidney parameters in PA patients.

Main Methods:

  • Renal studies including urinary protein excretion (albumin, beta2 microglobulin), glomerular filtration rate (GFR), and effective renal plasma flow (ERPF) were conducted.
  • 25 PA patients underwent pre- and post-treatment assessments (surgical cure or spironolactone).

Related Experiment Videos

  • A control group of EH patients was studied before and after antihypertensive therapy.

    • Main Results:

    • PA patients showed higher baseline urinary albumin and beta2 microglobulin excretion than EH patients.
    • Surgical cure of PA led to decreased blood pressure, reduced proteinuria, and a decline in GFR and ERPF.
    • EH patients experienced reduced proteinuria but stable GFR and ERPF after blood pressure control.
    • Spironolactone treatment in PA patients also resulted in decreased GFR and ERPF.

    Conclusions:

    • Primary aldosteronism is associated with specific kidney effects, including relative hyperfiltration, that are unmasked after aldosterone suppression.
    • These findings highlight the importance of addressing aldosterone excess for kidney health in PA patients.
    • PA-specific renal changes differ from those observed in essential hypertension even with similar blood pressure reduction.