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Related Experiment Videos

Chip-based microfluidic devices coupled with electrospray ionization-mass spectrometry.

Wang-Chou Sung1, Honest Makamba, Shu-Hui Chen

  • 1Department of Chemistry, National Cheng Kung University, No. 1 Ta-Hsueh Road, Tainan 701, Taiwan.

Electrophoresis
|April 1, 2005
PubMed
Summary

Microfluidic devices coupled with electrospray ionization-mass spectrometry (ESI-MS) offer improved performance through miniaturization. However, integrating sample preparation and introduction remains a significant challenge for these advanced analytical tools.

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Area of Science:

  • Analytical Chemistry
  • Chemical Engineering
  • Mass Spectrometry

Background:

  • Microfluidic devices are increasingly fabricated on diverse substrates for integration with electrospray ionization-mass spectrometry (ESI-MS).
  • Miniaturization of ESI chips has led to enhanced analytical performance compared to conventional methods.
  • Challenges persist in integrating multiple sample preparation steps and ESI sample introduction onto microfluidic platforms.

Purpose of the Study:

  • To review the technical advancements in microfluidic electrospray devices for mass spectrometry-based analysis.
  • To highlight the development and applications of microchip devices for ESI-MS from 1997 to 2004.
  • To focus on key publications demonstrating the scope of microchip ESI-MS technology.

Main Methods:

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  • Review of scientific literature published between 1997 and 2004.
  • Focus on microfluidic device fabrication for electrospray ionization.
  • Analysis of integrated sample preparation and ESI sample introduction techniques.

    • Main Results:

    • Significant progress in fabricating microfluidic ESI chips demonstrating improved performance.
    • Identification of challenges in the integration of complex sample preparation workflows.
    • Demonstration of diverse applications of microchip-based ESI-MS.

    Conclusions:

    • Microfluidic devices show great promise for miniaturized ESI-MS analysis.
    • Further research is needed to overcome integration challenges for comprehensive sample handling.
    • The reviewed period showcases substantial development in microchip ESI-MS technology.