Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Algid malaria].

Meditsinskaia Parazitologiia I Parazitarnye Bolezni

|April 2, 2005

Summary

This summary is machine-generated.

Algid malaria, a rare tropical malaria complication (0.37%), presents with shock, metabolic changes, and hypothermia. Its development involves red blood cell issues, TNF, acidosis, gastrointestinal damage, and septicemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical and diagnostic manifestations of tickborne mixed infection in combination with COVID-19.

Klinicheskaia laboratornaia diagnostika·2021

Same author

Response to letter to the editor regarding our paper "off-pump coronary artery-bypass grafting for patients with severely reduced left ventricular function-a justified strategy?" by Lima et al.

Journal of cardiac surgery·2021

Same author

[Time course of changes in cytokines (IFN-γ, IFN-α, IL-18, TNF-α) in the treatment of moderate influenza A (H1N1) pdm09 (2013-2016) with oseltamivir (Tamiflu) and umifenovir (Arbidol) alone and in combination with Kagocel].

Terapevticheskii arkhiv·2017

Same author

The effects of residual pump blood on patient plasma free haemoglobin levels post cardiac surgery.

Anaesthesia and intensive care·2016

Same author

Combination of ECMO and cytokine adsorption therapy for severe sepsis with cardiogenic shock and ARDS due to Panton-Valentine leukocidin-positive Staphylococcus aureus pneumonia and H1N1.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2016

Same author

[Trichinella autoinfection].

Meditsinskaia parazitologiia i parazitarnye bolezni·2015

Area of Science:

Tropical medicine
Infectious diseases
Pathophysiology

Background:

Algid malaria is a severe, infrequent complication of tropical malaria, affecting approximately 0.37% of cases.
It is defined by significant hemodynamic instability, including shock, profound metabolic disturbances, and hypothermia.

Observation:

Pathological mechanisms contributing to algid malaria include impaired microcirculation due to red blood cell alterations (cytoadherence, sequestration, rosetting).
Tumor necrosis factor (TNF) plays a role, inducing hypoglycemia, coagulopathy, and impaired erythropoiesis.
Gastrointestinal lesions, leading to ischemic damage and hypovolemia from fluid loss, are implicated.
The condition is often associated with concurrent gram-negative septicemia.

Findings:

Related Experiment Videos

The abstract outlines the multifactorial etiology of algid malaria, detailing the interplay of hematological, immunological, metabolic, and infectious factors.

It highlights the critical role of red blood cell dysfunction in microcirculatory compromise.

The contribution of gastrointestinal tract involvement and septicemia to the shock state is emphasized.

Implications:

Understanding these complex pathophysiological pathways is crucial for developing targeted therapeutic strategies for algid malaria.
Early recognition and management of hemodynamic and metabolic derangements are essential for improving patient outcomes.
Further research into the specific roles of TNF and septicemia may reveal novel treatment targets.