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Updated: Aug 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Micelles based on polyvinyl alcohol substituted with oleic acid for targeting of lipophilic drugs
B Luppi1, F Bigucci, T Cerchiara
1Department of Pharmaceutical Sciences, Bologna University, Bologna, Italy. bluppi@biocfarm.unibo.it
Abstract:
Polymeric micelles based on polyvinyl alcohol substituted with oleic acid were used as vehicles for progesterone and folic acid. The ability of this amphiphilic polymer to entrap lipophilic drugs and to generate stable micelles in aqueous neutral medium makes it a good candidate for drug delivery. The release of the loaded drugs in acidic environments represents another important property of these systems. Size of micelles, their stability, and their drug-loading capacity were evaluated, as well as the in vitro controlled-release profiles at pH 7.4 and 5.5.
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