Related Experiment Video
Updated: Aug 11, 2026
08:46
A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
Published on: July 26, 2017
Relationship between pulmonary function and lung cancer surgical outcome
1Thoracic Oncology Unit, Papworth Hospital, Papworth Everard, Cambridge, CB3 8RE, UK. thida.win@papworth.nhs.uk
The European Respiratory Journal
|April 2, 2005
Summary
Pulmonary function tests predict lung cancer surgery outcomes. Predicted lung function values, especially forced expiratory volume in one second (FEV1), are better surgical outcome predictors than absolute values.
Area of Science:
- Thoracic Surgery
- Pulmonary Medicine
- Oncology
Background:
- Current guidelines for lung cancer surgery investigation rely on outdated studies.
- Prospective evaluation of pulmonary function tests (PFTs) and surgical outcomes is needed.
Purpose of the Study:
- To prospectively assess the relationship between PFT results and surgical outcomes in lung cancer patients.
- To determine if PFTs, expressed as percentages of predicted values, can predict post-operative outcomes.
Main Methods:
- A cohort of 110 lung cancer patients undergoing surgery from 2001-2003 had full PFTs.
- Pre-operative and post-operative lung function was measured.
- Mortality, complication rates, and overall outcomes were analyzed in relation to PFTs.
Main Results:
- Hospital mortality was 3%, major complications occurred in 22%, and poor outcomes in 13%.
- Pre-operative forced expiratory volume in one second (FEV1) and diffusing capacity of the lung for carbon monoxide (D(L,CO)) were 79.4% and 73.6% predicted, respectively.
- Post-operative values decreased to 55.6% (FEV1) and 51.3% (D(L,CO)) predicted.
Conclusions:
- Lung function values as a percentage of predicted values are superior predictors of surgical outcome compared to absolute values.
- A pre-operative FEV1 threshold of 47% predicted offers high positive (0.90) and negative (0.67) predictive probabilities.
- Current guidelines may allow for lower FEV1 thresholds (45-50% predicted) for lung cancer surgery without increasing mortality.
Related Concept Videos
01:27Pneumothorax-II
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
01:25Pulmonary Function Tests
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...