The mineralocorticoid receptor: a journey exploring its diversity and specificity of action

Laurent Pascual-Le Tallec1, Marc Lombès

  • 1Institut National de la Santé et de la Recherche Médicale, Unité 693, Faculté de Médecine Paris-Sud, 63 rue Gabriel Péri, 94276 Le Kremlin Bicêtre, France.

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Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
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The Two-State Receptor Model01:29

The Two-State Receptor Model

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Adrenergic Receptors: β Subtype

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Drug-Receptor Interactions

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Transducer Mechanism: G Protein–Coupled Receptors

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