Related Experiment Video
Updated: Aug 18, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Thrombosis in a pregnant hemophilia A carrier after intrapartum recombinant factor VIII
Zoi Russell1, Dan Riconda, Lynda Pollack
1Department of Obstetrics and Gynecology, Arnold Palmer Hospital for Children and Women, Orlando Regional Healthcare, Orlando, Florida, USA. zoika1@yahoo.com
Background:
Symptomatic hemophilia A is a rare disorder in females. Pregnancy and delivery in such women can be life threatening. Obstetric management is challenging and requires a multidisciplinary approach to ensure a good outcome.
Case:
A woman with hemophilia A delivered by cesarean developed a deep vein thrombosis 10 days postpartum after recombinant factor VIII administration.
Conclusion:
Hemophilia A due to skewed X-inactivation is a rare cause of peripartum bleeding. Recombinant factor VIII administration can prevent hemorrhage during and after cesarean delivery but may be associated with development of deep vein thrombosis.
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