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Natriuretic peptides and mortality after stroke.
A M Mäkikallio1, T H Mäkikallio, J T Korpelainen
1Graduate School of Circumpolar Wellbeing, Health, and Adaptation, Centre for Arctic Medicine, University of Oulu, Finland. anne.makikallio@mail.suomi.net
Stroke
|April 2, 2005
Summary
Elevated levels of atrial natriuretic peptides (N-ANP) and brain natriuretic peptides (N-BNP) in acute stroke patients predict mortality. These natriuretic peptides are significantly higher in stroke and myocardial infarction patients compared to healthy individuals.
Area of Science:
- Cardiology
- Neurology
- Biomarkers
Background:
- Natriuretic peptides offer prognostic insights in diverse patient groups.
- The prognostic significance of natriuretic peptides in acute stroke patients remains largely uncharacterized.
- Elevated natriuretic peptide levels have been observed in acute stroke cases.
Purpose of the Study:
- To investigate the prognostic value of natriuretic peptides in patients experiencing acute ischemic stroke.
- To compare natriuretic peptide levels in acute stroke patients with those in acute myocardial infarction (AMI) patients and healthy controls.
Main Methods:
- A cohort of 51 first-ever ischemic stroke patients underwent clinical assessment and plasma N-ANP and N-BNP measurements during the acute phase.
- Patients were followed for an average of 44 months to assess all-cause mortality risk factors.
- Control groups included 51 AMI patients and 25 healthy subjects, matched for age and gender.
Main Results:
- Stroke patients exhibited N-ANP and N-BNP levels comparable to AMI patients but significantly higher than healthy controls.
- Elevated N-ANP and N-BNP levels were significant predictors of mortality in both stroke and AMI patients.
- These peptide levels remained independent predictors of post-stroke mortality after adjusting for key clinical factors.
Conclusions:
- Plasma natriuretic peptide levels are elevated during the acute phase of ischemic stroke.
- Elevated natriuretic peptides serve as significant predictors of mortality following stroke.
- This finding highlights the potential role of natriuretic peptides as prognostic biomarkers in acute stroke management.