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Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for
Bénédicte Puissant1, Francis Roubinet, Jérôme Dellacasagrande
1Laboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Faculté de médecine Toulouse-Rangueil, Toulouse, France.
Abstract:
We explored the impact of human ABO glycosyltransferase and Lewis and secretor fucosyltransferase polymorphisms in HIV infection. We found that, compared with healthy blood donors, HIV-infected patients display a significant decrease in Le(a-b+) phenotype frequencies. We showed that HIV binding on DC-SIGN-transduced Jurkat cells was inhibited by fucosyl bovine serum albumin. Our results suggest a slight protective effect of Lewis b antigen on HIV infection, possibly by the competition of Lewis antigens with HIV for binding to DC-SIGN.
