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Related Experiment Videos

Aggressive fibromatosis.

William M Mendenhall1, Robert A Zlotecki, Christopher G Morris

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA.

American Journal of Clinical Oncology
|April 2, 2005
PubMed
Summary
This summary is machine-generated.

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Optimal treatment for aggressive fibromatosis balances surgery, radiotherapy, and pharmacologic agents based on tumor characteristics. Early intervention and appropriate therapy selection are key to managing this rare condition and minimizing recurrence.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Aggressive fibromatosis, also known as desmoid tumors, are rare fibroblastic neoplasms.
  • These tumors exhibit unpredictable growth patterns and a high propensity for local recurrence, posing significant management challenges.

Purpose of the Study:

  • To review existing literature on aggressive fibromatosis.
  • To define optimal treatment strategies for patients diagnosed with this condition.

Main Methods:

  • Comprehensive literature review of studies on aggressive fibromatosis treatment.
  • Analysis of data regarding surgical resection, radiotherapy, and pharmacologic interventions.

Main Results:

  • High local recurrence rates are associated with positive surgical margins.

Related Experiment Videos

  • Radiotherapy demonstrates local control rates of 75-80% for gross disease or after incomplete resection.
  • Pharmacologic agents achieve objective response rates of 40-50%, with variable response durations.

    • Conclusions:

    • Optimal management is dictated by tumor location, extent, and resectability.
    • Surgery is recommended for completely resectable lesions with acceptable functional and cosmetic outcomes.
    • Radiotherapy is indicated for unresectable tumors and as adjuvant therapy for positive margins. Pharmacologic treatment is reserved for progressive disease post-local therapy.