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Related Experiment Videos

Communicating with Hedgehogs.

Joan E Hooper1, Matthew P Scott

  • 1Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 East 17th Avenue, Box 8018, Aurora, Colorado 80045, USA. joan.hooper@uchsc.edu

Nature Reviews. Molecular Cell Biology
|April 2, 2005
PubMed
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Hedgehog (Hh) protein signaling is crucial for tissue development. Aberrations in this pathway can cause birth defects and cancer, highlighting its importance in cellular regulation.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Signaling

Background:

  • Secreted Hedgehog (Hh) proteins mediate essential developmental signaling pathways.
  • Dysregulation of the Hh signal-transduction pathway is implicated in congenital abnormalities and oncogenesis.
  • Hh proteins form concentration gradients, eliciting distinct cellular responses at different thresholds.

Purpose of the Study:

  • To elucidate the fundamental mechanisms of Hedgehog (Hh) signal transduction.
  • To understand the role of Hh signaling in tissue and organ development.
  • To investigate the evolutionary conservation of the Hh cellular machinery.

Main Methods:

  • Analysis of Hh protein distribution and cellular responses in developing tissues.
  • Investigation of the molecular components involved in Hh signal transduction.

Related Experiment Videos

  • Comparative studies across metazoan species to assess evolutionary conservation.

    • Main Results:

    • Hedgehog (Hh) proteins are secreted and form gradients within tissues.
    • Cells exhibit distinct responses based on their proximity to Hh sources and the concentration thresholds encountered.
    • The core molecular machinery for Hh signal transduction demonstrates significant conservation throughout metazoan evolution.

    Conclusions:

    • Hedgehog (Hh) signaling is a fundamental process in metazoan development.
    • The precise control of Hh concentration gradients is critical for normal tissue formation.
    • The conserved nature of Hh pathway components suggests deep evolutionary importance.