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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

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[Ferritin and other acute phase proteins in various forms of coronary heart disease]

A D Paramonov, S V Moiseev, V V Fomin

    Klinicheskaia Meditsina
    |April 5, 2005
    PubMed

    Insights

    High serum ferritin, fibrinogen, and C-reactive protein (CRP) indicate unstable angina (IA) in coronary heart disease (CHD) patients. Ferritin may reflect atherosclerotic plaque destabilization, especially in IA.

    Area of Science:

    • Cardiovascular Medicine
    • Biochemistry
    • Clinical Diagnostics

    Background:

    • Coronary heart disease (CHD) encompasses various clinical presentations, including stable angina, painless myocardial ischemia (PMI), and unstable angina (IA).
    • Biomarkers such as ferritin, fibrinogen, and C-reactive protein (CRP) are investigated for their role in inflammation and cardiovascular risk.
    • Understanding the clinical significance of these markers in different CHD forms is crucial for patient management.

    Purpose of the Study:

    • To determine the clinical importance of elevated serum ferritin, fibrinogen, and CRP levels in patients with different forms of coronary heart disease (CHD).
    • To assess the relationship between these biomarkers and the clinical presentation of CHD, particularly unstable angina (IA).

    Main Methods:

    • Sixty patients with diagnosed CHD (stable angina, PMI, or IA) identified via stress echocardiography were studied.
    • A control group of 20 individuals with cardiovascular risk factors but no CHD was included.
    • Routine clinical examinations and biochemical blood tests, including serum levels of ferritin, fibrinogen, CRP, iron, and total iron-binding capacity (TIBC), were performed.

    Main Results:

    • Serum levels of CRP, fibrinogen, and ferritin were significantly highest in patients with unstable angina (IA) compared to the control group.
    • No significant differences in serum iron or TIBC were observed between groups.
    • Significant correlations were found between ferritin and CRP in all CHD groups, and between ferritin and fibrinogen in IA patients, suggesting ferritin's role as an acute-phase reactant in CHD destabilization.

    Conclusions:

    • Elevated serum ferritin, in conjunction with fibrinogen and CRP, should be considered an indicator of acute phase response in patients with coronary heart disease (CHD).
    • Particularly in patients with unstable angina (IA), serum ferritin may signify atherosclerotic plaque destabilization.
    • These findings highlight the potential of ferritin as a biomarker for monitoring disease activity in CHD.

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