Distinct cytokine release profiles from human endothelial and THP-1 macrophage-like cells exposed to different amphotericin B formulations
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Updated: Aug 18, 2026

Establishment of an In vitro System to Study Intracellular Behavior of Candida glabrata in Human THP-1 Macrophages
Published on: December 10, 2013
Lloyd W Turtinen1, Lindsay A Bremer, David N Prall
1Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI 54702, USA. Turtinen@uwec.edu
Abstract:
Amphotericin B(AmB) formulations, Fungizone, and Amphotec caused substantially greater proinflammatory cytokine release than AmBisome (L-AMB) and Abelcet in TPA differentiated THP-1 macrophages as determined by antibody based protein arrays. Lipopolysaccharide but not AmB induced significant pro-inflammatory cytokines in human endothelial cells.
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