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Updated: Aug 18, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
[The effect of dog bilateral distraction osteogensis in temporomandibular joint]
Nuo Zhou1, Shao-hua Song, Hua-ming Mai
1Dept. of Oral and Maxillofacial Surgery, School of Stomtology, Guangxi Medical University, Nanning 530021, China.
Objective:
To investigate the effect of bilateral mandibular distraction osteogenesis in the condyles.
Methods:
16 adult hybrid dogs were randomly divided into normal control group and experiment group. Experimental dogs underwent bilateral mandibular osteodistraction at a rate of 1 min/day. 4 dogs were killed respectively in distraction period, 2 and 8 weeks after completion of 10 days distraction. The bilateral condyles specimens were harvested and examined with histological and immunohistochemical methods.
Results:
Compared with normal control group, various degrees of irregularities and erosion were found in fibrocartilage of condyle in experiment group, including damage in fibrous layer, hyperplasia layer and proliferative layer and osteogenic activity in cartilage layer. A significant increase of TGF-beta1 expression was also found in experiment groups. TGF-beta1 positive staining was noted in hypertrophic cell, matrix and chondroblast, osteoblast and matrix in osteogenic activity areas. These changes were the most obvious in 2 weeks after completion of distraction.
Conclusion:
Gradual bilateral mandibular distraction at a rate of 1 mm/day brought degenerative changes of condyle, but the changes are reversible.
