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[Angiotensin converting enzyme gene polymorphism and type 2 diabetic nephropathy]
Lan Liao1, Min-xiang Lei, Hui-ling Chen
1Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China.
Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|April 5, 2005
Summary
The angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is not associated with the development of diabetic nephropathy (DN) in Type 2 diabetic patients. The DD genotype does not appear to be a useful genetic marker for predicting DN in this population.
Area of Science:
- Genetics
- Nephrology
- Endocrinology
Context:
- Diabetic nephropathy (DN) is a significant complication of Type 2 diabetes.
- Genetic factors may influence DN susceptibility.
- The angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is a candidate gene for DN.
Purpose:
- To prospectively investigate the association between ACE gene I/D polymorphism and the development of DN in Type 2 diabetic patients.
- To determine if the DD genotype serves as a predictive marker for DN.
Summary:
- A 5-year prospective study followed 66 Type 2 diabetic patients with normal albuminuria.
- Patients were genotyped for ACE I/D polymorphism and monitored for urinary albumin excretion (UAE), serum creatinine (Scr), and HbA1c.
- No significant differences in clinical parameters or DN incidence were observed among II, ID, and DD genotype groups.
Impact:
- This study suggests that ACE gene I/D polymorphism is not a clinically useful genetic marker for predicting DN in Type 2 diabetic patients of Chinese descent.
- Findings indicate no association between ACE gene I/D polymorphism and the genesis or progression of DN in this cohort.