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Hemicolectomy with concomitant heated intraperitoneal chemotherapy: a case study
Jeffery P Edwards1, Britt Rodenberg, Scott D Niles
1University of Iowa Perfusion Technology Program, Iowa City, Iowa 52242, USA.
The Journal of Extra-Corporeal Technology
|April 5, 2005
Summary
Heated intraperitoneal chemotherapy (HIPEC) with Mitomycin-C offers a novel treatment for colon adenocarcinoma. This study details a custom perfusion circuit successfully used in a patient, demonstrating HIPEC
Area of Science:
- Oncology
- Surgical Oncology
- Chemotherapy Administration
Background:
- Heated intraperitoneal chemotherapy (HIPEC) is an emerging treatment for colon adenocarcinoma.
- Detailed perfusion circuitry and techniques for HIPEC are not well-documented.
- This study addresses the need for described HIPEC protocols in colon cancer treatment.
Observation:
- A custom-designed perfusion circuit was developed in consultation with surgical services.
- Institutional approval and informed consent were obtained for a 58-year-old female patient.
- The procedure involved surgical debulking, right hemicolectomy, and HIPEC administration.
Findings:
- A modified custom circuit with a roller pump was utilized, priming with Dianeal PD-2 to achieve 41°C.
- Perfusate containing Mitomycin-C was circulated at 600-800 mL/min for 60 minutes at 41°C, followed by an additional dose.
- The patient tolerated the HIPEC procedure well and was discharged on postoperative day 7.
Implications:
- This case report successfully demonstrates the application of a perfusion-administered HIPEC regimen.
- The described technique provides a valuable reference for the integration of HIPEC in colon adenocarcinoma treatment.
- Successful patient tolerance and discharge suggest the feasibility and potential efficacy of this HIPEC approach.