Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement receptors regulate lipopolysaccharide-induced T-cell stimulation.

Ziya Kaya1, Theresa Tretter, Jens Schlichting

  • 1Department of Internal Medicine III--Cardiology, University of Heidelberg, Heidelberg, Germany. ziya_kaya@med.uni-heidelberg.de

Immunology
|April 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magel2 deficiency promotes cardiac remodeling and increases arrhythmogenic susceptibility in a mouse model relevant to Prader-Willi and Schaaf-Yang syndromes.

Clinical science (London, England : 1979)·2026
Same author

Timely hospital discharge in TAVI patients: towards a patient-centered care pathway.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Impact of a Clinical Valve Coordinator on Hospital Length of Stay and Patient Outcomes: Results From the BENCHMARK Registry.

Structural heart : the journal of the Heart Team·2026
Same author

Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium.

Nature cardiovascular research·2025
Same author

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease.

European heart journal·2025
Same author

Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial.

European heart journal·2025
Same journal

Epidermal Dominance of Metabolically Constrained Immune Niches Underpins Immune Activation Signatures and Clinical Severity in Psoriatic Disease.

Immunology·2026
Same journal

Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders.

Immunology·2026
Same journal

Immune Checkpoints in Leukaemia as Gatekeepers of Immuno-Modulation.

Immunology·2026
Same journal

Senescent Human Liver Endothelial Cells Mediate CD4<sup>+</sup> T Cell Recruitment via ICOSL.

Immunology·2026
Same journal

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> Double Negative T Cells in lpr Lupus Mice.

Immunology·2026
Same journal

Epigenetic Gene Networks Governing Immune State Transitions Across the Lifespan.

Immunology·2026
See all related articles

Complement receptors type 1 and 2 (CR1/CR2) are newly found on T cells. These receptors significantly influence T cell activation by lipopolysaccharide (LPS), suggesting a novel immune modulation role.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Complement receptors type 1 and 2 (CR1/CR2) are recognized for their role in enhancing adaptive immunity.
  • These receptors are typically found on B cells, follicular dendritic cells, and activated granulocytes in mice.
  • Previous research indicated CR1/CR2 expression on a specific subset of T cells (CD44high and CD62Llow).

Purpose of the Study:

  • To investigate the expression of CR1/CR2 on broader T cell subsets.
  • To determine the role of CR1/CR2 in T cell activation in response to lipopolysaccharide (LPS).

Main Methods:

  • Flow cytometry was used to detect CR1/CR2 expression on CD4+ and CD8+ T cells.
  • T cell activation was assessed by measuring the upregulation of CD25 and CD69.

Related Experiment Videos

  • Comparisons were made between T cells from CR1/CR2 sufficient (Cr+/+) and deficient (Cr-/-) mice stimulated with LPS.

    • Main Results:

    • CR1/CR2 expression was confirmed on both CD4+ and CD8+ T cell subsets.
    • LPS stimulation led to a marked upregulation of CD25 and CD69 on T cells from Cr+/+ mice.
    • T cells from Cr-/- mice exhibited significantly lower upregulation of CD25 and CD69 upon LPS stimulation.

    Conclusions:

    • CR1/CR2 are expressed on both CD4+ and CD8+ T cells.
    • CR1/CR2 play a significant role in modulating T cell activation induced by LPS.
    • These findings reveal a novel mechanism involving CR1/CR2 in T cell activation pathways.