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Updated: Aug 18, 2026

Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance
Published on: January 3, 2012
Selective detection of saxitoxin over tetrodotoxin using acridinylmethyl crown ether chemosensor
Robert E Gawley1, Muthian Shanmugasundaram, John B Thorne
1Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA. bgawley@uark.edu
Abstract:
At pH 7.1, saxitoxin decomposes to produce a trace impurity that can interfere with fluorescence sensing when using irradiation wavelengths near 325 nm. The fluorophore acridine is found to be a suitable component of arylmethyl crown ether chemosensors for the fluorescent detection of saxitoxin. These sensors are selective for the detection of saxitoxin over tetrodotoxin.
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