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Variation in inpatient diagnostic testing and management of bronchiolitis
Dimitri A Christakis1, Charles A Cowan, Michelle M Garrison
1Department of Pediatrics, University of Washington, Seattle, Washington, USA. dachris@u.washington.edu
Insights
Significant variations in bronchiolitis diagnosis and treatment exist across hospitals. Factors like antibiotic use and severity scores impact length of stay, highlighting the need for standardized care guidelines.
Area of Science:
- Pediatric hospital medicine
- Respiratory infections
- Health services research
Background:
- Bronchiolitis is a common pediatric respiratory infection.
- Little is known about variations in its diagnosis and management.
- Understanding these variations is crucial for improving patient care and resource allocation.
Purpose of the Study:
- To document variations in bronchiolitis diagnosis, treatment, length of stay (LOS), and readmission rates.
- To identify modifiable factors associated with longer LOS and antibiotic use.
Main Methods:
- Analysis of patient-level data from 30 children's hospitals (October 2001-September 2003).
- Inclusion of infants under 1 year hospitalized for bronchiolitis.
- Multivariate and regression analyses to assess hospital variations and predictors of LOS and antibiotic use.
Main Results:
- 17,397 infants analyzed; mean LOS 2.97 days.
- Significant hospital-level variation in LOS, diagnostic tests, medications, and readmissions.
- Higher severity scores, antibiotics, bronchodilators, and corticosteroids predicted longer LOS; severity scores and cultures predicted antibiotic use.
Conclusions:
- Considerable unexplained variation exists in inpatient bronchiolitis management.
- Hospital practices significantly contribute to variations in care.
- Development of national guidelines and further research into optimal management strategies are recommended.
Objectives:
We know little about the variation in diagnosis and management of bronchiolitis. The objectives of this study were (1) to document variations in treatment and diagnostic approaches, lengths of stay (LOSs), and readmission rates and (2) to determine which potentially modifiable process of care measures are associated with longer LOSs and antibiotic usage.
Methods:
We used the Pediatric Health Information System, which includes demographic, diagnostic, and detailed patient-level data on 30 large children's hospitals. We examined infants who were younger than 1 year and hospitalized for bronchiolitis (October 2001-September 2003). Multivariate analysis of variance was used to determine whether the variance in the outcomes was hospital related after controlling for other covariates. Linear regression was used to model predictors of increased LOS. Logistic regression was used to model antibiotic usage. Analyses were stratified by age group (<3 months and 3-11 months).
Results:
A total of 17397 patients were included in the analysis. The mean LOS was 2.97 days; 72% of patients received chest radiographs, 45% received antibiotics, and 25% received systemic steroids. The mean LOS varied considerably across hospitals (range: 2.40-3.90 days), and hospital remained a significant contributor to LOS variation after controlling for our covariates. Variations in the use of diagnostic tests and medications as well as readmission rates also existed and also remained significant after controlling for covariates. The factors associated with the greatest increases in LOS in the regression analyses included higher severity scores and use of antibiotics, bronchodilators, and corticosteroids. The strongest predictors of antibiotic use in the logistic regression analyses were higher severity scores and receipt of a blood or cerebrospinal fluid culture. Receiving a chest radiograph was a significant predictor of antibiotic use in older but not younger infants.
Conclusions:
Considerable, unexplained variation exists in the inpatient management of bronchiolitis. The development of national guidelines and controlled trials of new therapies and different management approaches are indicated.
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