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Updated: Aug 18, 2026

Bovine Ovarian Cortex Tissue Culture
Published on: January 14, 2021
21-deoxycortisone (17alpha-hydroxy-4-pregnene-3,11,20-trione)
Raja Dey1, Vratislav Langer, P Roychowdhury
1Centre for Structural Biology, Department of Chemistry and Bioscience, Chalmers University of Technology, Box 462, Gothenburg 40530, Sweden.
Abstract:
The title compound, C21H28O4, a synthetic glucocorticoid, crystallizes with a single molecule in the asymmetric unit. Ring A is almost in a half-chair conformation, rings B and C are almost in chair conformations, and ring D is between a twist and a 13beta-envelope conformation. The A/B ring junction is quasi-trans, whereas the B/C and C/D ring junctions both approach trans characteristics. The molecule as a whole is slightly convex towards the beta side, with an angle of 9.60 (2) degrees between the C10-C19 and C13-C18 vectors. Molecular-packing and hydrogen-bonding (both intra- and intermolecular) interactions play a major role in the structural association of the compound.
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