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Updated: Aug 18, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
(2Z)-3-(5-Hydroxy-4-oxo-4H-chromen-3-yl)acrylonitrile
Ramiro Araya-Maturana1, Jorge Heredia-Moya, Hernán Pessoa-Mahana
1Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile. raray@ciq.uchile.cl
Abstract:
The title compound, C12H7NO3, consists of a chromone moiety substituted in position 3 with an acrylonitrile group in a Z configuration. The two planar groups are twisted with respect to one another. The only significant hydrogen bond in the structure is an intramolecular O-H...O bond. pi-pi contacts connecting aromatic groups and C-H...O intermolecular weak interactions lead to a supramolecular layer arrangement.
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