Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tropical pulmonary eosinophilia.

E A Ottesen1, T B Nutman

  • 1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

Annual Review of Medicine
|January 1, 1992
PubMed
Summary

Tropical pulmonary eosinophilia, a parasitic lung infection, causes respiratory issues and high eosinophil counts. Persistent lung inflammation after treatment may lead to fibrosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human innate lymphoid cells (ILCs) in filarial infections.

Parasite immunology·2017
Same author

Dysregulation of interleukin 5 expression in familial eosinophilia.

Allergy·2017
Same author

Looking beyond the induction of Th2 responses to explain immunomodulation by helminths.

Parasite immunology·2015
Same author

Brugia malayi infective larvae fail to activate Langerhans cells and dermal dendritic cells in human skin.

Parasite immunology·2014
Same author

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.

Science (New York, N.Y.)·2014
Same author

Immunology of lymphatic filariasis.

Parasite immunology·2013

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Tropical pulmonary eosinophilia (TPE) is a parasitic lung disease.
  • It is characterized by pulmonary infiltrates with eosinophilia (PIE).
  • TPE is caused by Wuchereria bancrofti or Brugia malayi.

Purpose of the Study:

  • To describe the clinical presentation and diagnostic features of TPE.
  • To investigate the relationship between eosinophilic alveolitis and lung function.
  • To assess the persistence of alveolitis after treatment.

Main Methods:

  • Review of clinical presentation, diagnostic findings, and treatment outcomes.
  • Analysis of lung function tests and chest radiographs.
  • Evaluation of serum IgE and antifilarial antibody levels.

Main Results:

  • TPE presents with nocturnal cough, dyspnea, wheezing, fever, fatigue, and eosinophilia (>3000/µL).
  • Diagnosis is supported by tropical residence, high IgE and antifilarial antibodies, and response to diethylcarbamazine.
  • Persistent low-grade alveolitis is observed in nearly half of patients post-treatment, linked to interstitial fibrosis.

Conclusions:

  • TPE is a distinct PIE syndrome with specific clinical and serological markers.
  • Compromised lung diffusion capacity correlates with eosinophilic alveolitis severity.
  • Persistent alveolitis post-treatment is a risk factor for progressive interstitial fibrosis in TPE.

Related Experiment Videos