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Genetics and the variability of treatment response in asthma
1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.
Abstract:
Pharmacogenetics is the study of how genetic differences influence the variability in patients' responses to therapy. Using specific examples in asthma, I will define the concepts of variability in response to therapy in asthma. I will then use the relationship between specific genetic polymorphisms and the response to beta-adrenergic agonists and leukotriene modifiers to illustrate pharmacogenetic interactions and to acquaint the reader with the applicability of these findings to clinical practice.
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