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Related Experiment Videos

Amyloids--a functional coat for microorganisms.

Martijn F B G Gebbink1, Dennis Claessen, Barend Bouma

  • 1Department of Haematology, Thrombosis and Haemostasis Laboratory, Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Nature Reviews. Microbiology
|April 5, 2005
PubMed
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Microbial amyloids, protein structures found on bacteria and fungi, aid in substrate invasion. In animal hosts, these amyloids activate proteases, influencing inflammation, matrix remodeling, and blood coagulation, potentially causing severe complications.

Area of Science:

  • Microbiology
  • Biochemistry
  • Pathology

Background:

  • Amyloids are filamentous protein structures characterized by a cross-beta structure.
  • While often associated with mammalian degenerative diseases, amyloids are also found on microbial cell surfaces.

Purpose of the Study:

  • To investigate the role of microbial amyloids in host-pathogen interactions.
  • To understand how microbial amyloids influence host physiological processes.

Main Methods:

  • Analysis of amyloid structure and function.
  • In vitro and in vivo studies examining host protease activation by microbial amyloids.

Main Results:

  • Microbial amyloids facilitate invasion of abiotic and biotic substrates.

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  • These amyloids activate host proteases involved in hemostasis, inflammation, and extracellular matrix remodeling.
  • Amyloid-mediated protease activation impacts blood coagulation.

    • Conclusions:

    • Microbial amyloids play a significant role in host colonization and pathogenesis.
    • The interaction of microbial amyloids with host proteases can lead to adverse health outcomes, including life-threatening complications.