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Updated: Aug 18, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Immunotherapy in metastatic renal cell carcinoma
Karl Rohrmann1, Michael Staehler, Nikolas Haseke
1Department of Urology, Ludwig Maximilian University of Munich-Grosshadern, Grosshadern Medical Center, Marchioninistrasse 15, 81377 Munich, Germany. Karl.Rohrmann@med.uni-muenchen.de
Abstract:
Metastatic renal cell carcinoma has a poor prognosis. Conventional therapies such as chemotherapy, radiation or hormonal treatment have hardly any effect on the progression of this disease. As renal cell carcinoma seems to be an immunogenic tumor, several immunotherapeutic approaches with different response rates have been developed since the early 1990s. We present an overview of various immunotherapeutic approaches such as cytokine-based regimes, with and without different cytotoxic chemotherapy, of metastatic renal cell carcinoma. In addition, local therapies (e.g. inhalation of interleukin-2) are reviewed.
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