Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed orthostatic intolerance.

D H Streeten1, G H Anderson

  • 1Department of Medicine, State University of New York Health Science Center, Syracuse 13210.

Archives of Internal Medicine
|May 11, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of milk protein intake and casein-to-whey ratio in breakfast meals on postprandial glucose, satiety ratings, and subsequent meal intake.

Journal of dairy science·2018
Same author

The effects of potatoes and other carbohydrate side dishes consumed with meat on food intake, glycemia and satiety response in children.

Nutrition & diabetes·2016
Same author

A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats.

Nutrition & diabetes·2015
Same author

Multivitamin supplementation during pregnancy alters body weight and macronutrient selection in Wistar rat offspring.

Journal of developmental origins of health and disease·2014
Same author

The effect of high multivitamin diet during pregnancy on food intake and glucose metabolism in Wistar rat offspring fed low-vitamin diets post weaning.

Journal of developmental origins of health and disease·2014
Same author

The role of alginates in regulation of food intake and glycemia: a gastroenterological perspective.

Critical reviews in food science and nutrition·2014
Same journal

Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

Archives of internal medicine·2017
Same journal

Occult Carbon Monoxide Poisoning-Reply.

Archives of internal medicine·2017
Same journal

Acquired Immune Deficiency Syndrome-Reply.

Archives of internal medicine·2017
Same journal

Heparin Side Effects-Reply.

Archives of internal medicine·2017
Same journal

Humanizing primary care medicine begins with stress.

Archives of internal medicine·2017
Same journal

Legend omitted and number misrepresented.

Archives of internal medicine·2013
See all related articles

Delayed orthostatic hypotension, characterized by a significant blood pressure drop after prolonged standing, affects patients with symptoms like lightheadedness and syncope. This condition is often correctable with interventions such as pressure suits.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Disorders
  • Clinical Medicine

Background:

  • Orthostatic hypotension (OH) is a common cause of dizziness and syncope.
  • Traditional diagnosis involves assessing blood pressure changes immediately after standing.
  • Some patients experience delayed symptoms, suggesting a different pathophysiological mechanism.

Purpose of the Study:

  • To investigate a specific form of delayed orthostatic hypotension (DOH).
  • To identify the underlying mechanisms contributing to DOH.
  • To evaluate potential therapeutic interventions for DOH.

Main Methods:

  • Continuous blood pressure monitoring in seven patients presenting with orthostatic symptoms.
  • Pharmacological and physiological assessments including plasma catecholamines, cortisol, aldosterone, and norepinephrine infusions.

Related Experiment Videos

  • Evaluation of treatment response using a pressure suit.

    • Main Results:

    • Patients exhibited severe blood pressure drops and syncope only after 13-30 minutes of standing.
    • Normal or elevated norepinephrine release was observed, with some patients showing impaired venous innervation.
    • Pressure suit inflation effectively corrected the hypotension and symptoms.

    Conclusions:

    • Delayed orthostatic hypotension is a distinct clinical entity causing significant morbidity.
    • The condition appears to involve complex autonomic and vascular dysregulation.
    • Therapeutic strategies, including mechanical support, can effectively manage DOH.