Related Experiment Video
Updated: Aug 18, 2026

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
Published on: February 3, 2023
[Current understanding of primary biliary cirrhosis]
Aim:
To examine characteristics of the course of primary biliary cirrhosis (PBC).
Material And Methods:
The study of 150 PBC patients aged 26-82 years used clinical, biochemical, immunological and morphological methods.
Results:
Antimitochondrial antibodies of type M2 (AMAM2) were detected in 85.4% patients with PBC. A positive correlation was found between clinicobiochemical activity of the disease and number of AMAM2. AMAM2-positive patients more frequently had extrahepatic manifestations, overlap syndrome, higher biochemical and immunological activity vs AMAM2-negative patients.
Conclusion:
The following variants of PBC course were identified: classic AMAM2-positive, AMAM2-negative, overlapping of PBC and autoimmune hepatitis. Concentration of AMAM2 has diagnostic and prognostic value in PBC.
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