Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microfluidic platform for the generation of organic-phase microreactors.

Zuzanna T Cygan1, João T Cabral, Kathryn L Beers

  • 1Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 6, 2005
PubMed
Summary

Researchers developed solvent-resistant microfluidic devices using thiolene-based resins for organic synthesis. These devices enable controlled droplet generation and facilitate organic-phase reactions, showcasing their utility in chemical synthesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spectroscopic and optical imaging of surfactant-mediated water diffusion and removal pathways in triglyceride films.

Journal of colloid and interface science·2026
Same author

Liquid crystalline order delays crystallisation in mixed surfactant systems.

Soft matter·2026
Same author

Navigating the labyrinth of isotropic wrinkling: design, fabrication, characterization, and applications.

Materials horizons·2026
Same author

Curvature Dynamics of PEGDA Asymmetric Networks via Frontal Photopolymerization: Effect of Chain Length and Optical Attenuation.

Macromolecules·2026
Same author

Rapid Nanocellulose Wet Nanoimprint Lithography for Tunable Structural Color.

ACS nano·2025
Same author

Survey of agricultural plastic waste in the American Midwest: Usage and disposal.

Waste management (New York, N.Y.)·2025

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Organic Chemistry

Background:

  • Microfluidic devices offer precise control over chemical reactions.
  • Traditional microfluidic materials often lack stability in organic solvents.
  • Developing robust microfluidic platforms for organic synthesis is crucial.

Purpose of the Study:

  • To fabricate microfluidic devices with enhanced stability in organic solvents.
  • To demonstrate the controlled generation and manipulation of organic droplets.
  • To showcase the application of these devices in performing organic synthesis reactions.

Main Methods:

  • Utilized rapid prototyping photolithography with a thiolene-based resin.
  • Quantified polymer matrix swelling in various organic solvents.

Related Experiment Videos

  • Generated discrete organic droplets (hexanes, toluene) within an aqueous matrix using SDS surfactant.
  • Controlled droplet size and separation by varying flow rates.
  • Demonstrated organic synthesis via alkene bromination within benzene droplets.

    • Main Results:

    • Fabricated microfluidic devices exhibited stability against aliphatic and aromatic organic solvents.
    • Achieved uniform droplet generation and precise control over droplet size and spacing.
    • Successfully performed organic-phase synthetic reactions (alkene bromination) within the generated droplets.
    • Demonstrated tunable droplet composition by adjusting flow rates of organic streams.

    Conclusions:

    • Thiolene-based resins are suitable for fabricating solvent-resistant microfluidic devices.
    • The developed microfluidic platform enables efficient droplet-based organic synthesis.
    • This technology holds promise for applications in high-throughput chemical synthesis and reaction optimization.