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Published on: December 4, 2011
Erythema multiforme following polymorphic light eruption: a report of two cases
E A Fraser-Andrews1, R Morris-Jones, L Novakovic
1Department of Photobiology, St. John's Institute of Dermatology, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. efraser-andrews@doctors.org.uk
Clinical and Experimental Dermatology
|April 6, 2005
Summary
Polymorphic light eruption episodes preceded erythema multiforme in two patients. Prophylactic treatment for light eruption prevented erythema multiforme, indicating a potential link between these conditions.
Area of Science:
- Dermatology
- Immunology
Background:
- Polymorphic light eruption (PLE) is a common photosensitive disorder.
- Erythema multiforme (EM) is an acute, self-limiting hypersensitivity reaction.
Observation:
- Two patients experienced recurrent erythema multiforme (EM) after episodes of polymorphic light eruption (PLE).
- EM occurred on both sun-exposed and non-exposed skin areas.
Findings:
- Prophylactic treatment of PLE with PUVA (psoralen plus ultraviolet A) and/or systemic corticosteroids (prednisolone) or cyclosporine prevented subsequent EM development.
- This suggests a potential relationship between PLE and EM.
Implications:
- EM may arise as a response to the same underlying antigen triggering PLE.
- Further research into shared causative factors for PLE and EM is warranted.
- Understanding this link may lead to improved therapeutic strategies for both conditions.
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