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Circulating YKL-40 levels during human endotoxaemia.

J S Johansen¹, K S Krabbe, K Møller

¹Department of Rheumatology Q107, University of Copenhagen, Herlev Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. julia.johansen@post3.tele.dk

Clinical and Experimental Immunology

|April 6, 2005

Summary

Plasma YKL-40 levels significantly increase following endotoxin injection in healthy volunteers, suggesting a role for YKL-40 in infection responses.

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Area of Science:

Immunology
Biochemistry

Background:

YKL-40 is a protein secreted by macrophages and neutrophils.
Elevated circulating YKL-40 is observed in patients with bacterial infections.

Purpose of the Study:

To evaluate plasma YKL-40 changes after Escherichia coli endotoxin administration in healthy volunteers.
To investigate the functional role of YKL-40 in infection models.

Main Methods:

Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma YKL-40.
Eight healthy volunteers received injections of E. coli endotoxin or saline.
Plasma samples were collected at 0, 2, 4, 8, 24, and 32 hours post-injection.

Main Results:

Plasma YKL-40 levels increased significantly after endotoxin injection compared to saline (P < 0.001).

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YKL-40 levels rose from a baseline of 31 microg/l to a maximum of 159 microg/l at 24 hours post-endotoxin.

The observed increase in YKL-40 was statistically significant (P < 0.01).

Conclusions:

Plasma YKL-40 concentration increases in response to endotoxin challenge.
These findings suggest YKL-40 plays a functional role during infection.
YKL-40 may serve as a biomarker for infectious processes.