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Alendronate-induced chemical laryngitis
M F Bhutta1, M Rance, D Gillett
1Department of Otolaryngology-Head and Neck Surgery, Royal Sussex County Hospital, Eastern Road, Brighton BN2 5BE, UK. m.bhutta@doctors.net.uk
The Journal of Laryngology and Otology
|April 6, 2005
Summary
Alendronate, a bisphosphonate for osteoporosis, can cause esophageal issues. This case study details laryngitis from laryngeal contact with alendronate and its successful management.
Area of Science:
- Pharmacology
- Gastroenterology
- Otolaryngology
Background:
- Alendronate is a widely prescribed bisphosphonate medication for treating osteoporosis.
- Known gastrointestinal side effects of alendronate include esophageal irritation and ulceration.
Observation:
- A case report details a patient experiencing laryngitis.
- The laryngitis was attributed to temporary contact between alendronate and the laryngeal mucosa.
Findings:
- Transient contact with laryngeal mucosa can induce laryngitis.
- The condition was successfully managed, indicating potential treatment pathways.
Implications:
- Highlights a rare but significant side effect of alendronate beyond the esophagus.
- Informs clinicians about a broader spectrum of potential alendronate-induced mucosal injuries.
- Suggests the importance of careful medication administration and patient counseling.