Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Personality changes in Alzheimer's disease.

A Chatterjee1, M E Strauss, K A Smyth

  • 1Alzheimer Center, Case Western Reserve University, Cleveland, Ohio.

Archives of Neurology
|May 1, 1992
PubMed
Summary

Personality changes in Alzheimer's disease (AD) involve systematic shifts in traits like neuroticism and extroversion. Caregivers reported significant alterations, suggesting consistent patterns across patients with AD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of glutathione levels on radiation-induced chromosomal DNA damage and repair in human peripheral lymphocytes.

Mutation research·2009
Same author

Hydrogen-bond mediated transitional adlayer of glycine on Si(111)7 x 7 at room temperature.

The Journal of chemical physics·2009
Same author

Nematicidal principles from two species of lamiaceae.

Journal of nematology·2009
Same author

Use of sequence motifs as barcodes and secondary structures of internal transcribed spacer 2 (ITS2, rDNA) for identification of the Indian liver fluke, Fasciola (Trematoda: Fasciolidae).

Bioinformation·2009
Same author

Molecular characterization of Gastrodiscoides hominis (Platyhelminthes: Trematoda: Digenea) inferred from ITS rDNA sequence analysis.

Parasitology research·2009
Same author

Determination of total cationic and total anionic arsenic species in oyster tissue using microwave-assisted extraction followed by HPLC-ICP-MS.

Talanta·2008

Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Personality changes in Alzheimer's disease (AD) are not fully understood.
  • Postulated changes include accentuation of premorbid personality, systematic trait shifts, or subtype-specific alterations.
  • Investigating these patterns is crucial for understanding AD's impact on personality.

Purpose of the Study:

  • To determine the nature of personality changes in Alzheimer's disease.
  • To differentiate between personality accentuation, systematic shifts, and subtype-specific changes.
  • To examine the relationship between premorbid personality and subsequent psychiatric symptoms in AD.

Main Methods:

  • Caregivers of Alzheimer's disease patients completed a comprehensive personality inventory.

Related Experiment Videos

  • The inventory was standardized for informant-based assessments.
  • Data analysis focused on observed behavioral changes reported by caregivers.

    • Main Results:

    • Caregivers reported increased neuroticism and decreased extroversion and conscientiousness in AD patients.
    • Smaller decreases were noted in agreeableness and openness.
    • Systematic shifts in neuroticism, extroversion, agreeableness, and openness were observed across patients.
    • Depressive features correlated with higher neuroticism; paranoid delusions correlated with hostility.

    Conclusions:

    • Alzheimer's disease is associated with systematic shifts in personality traits.
    • Premorbid personality traits may influence the development of psychiatric symptoms in AD.
    • Understanding these personality changes is vital for comprehensive AD patient care.