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Embolia cutis medicamentosa.

Doulat Rai Bajaj1, Aijaz Ahmed Qureshi

  • 1Department of Dermatology, Liaquat University of Medical & Health Sciences, Jamshoro. doulat01@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|April 6, 2005
PubMed
Summary

Embolia cutis medicamentosa, or Nicolau syndrome, is a rare skin necrosis after injections. This case highlights a patient who developed this condition following a diclofenac sodium injection, showing the importance of recognizing this adverse drug reaction.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Embolia cutis medicamentosa (Nicolau syndrome) is a rare but severe adverse reaction following intramuscular injections.
  • It is characterized by acute, localized skin and subcutaneous necrosis.

Observation:

  • A young woman from a rural area presented with an ulcerated lesion on her left deltoid region.
  • The lesion exhibited irregular contours and livedoid features.
  • She reported developing the condition after receiving an intramuscular injection of diclofenac sodium.

Findings:

  • Histopathological examination of the biopsied tissue revealed dead keratinocytes.
  • Degenerative changes were observed in both the epidermis and dermis.
  • These findings are consistent with Embolia cutis medicamentosa.

Implications:

  • This case underscores the potential risk of Embolia cutis medicamentosa following diclofenac sodium injections.
  • Prompt wound management led to improvement, though a residual scar remained.
  • Awareness among healthcare providers is crucial for early diagnosis and management of this iatrogenic condition.

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