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Related Experiment Videos

Persistent diabetic macular edema is associated with elevated hemoglobin A1c.

Diana V Do1, Syed Mahmood Shah, Jennifer U Sung

  • 1Vitreoretinal Service, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

American Journal of Ophthalmology
|April 6, 2005
PubMed
Summary

Type 2 diabetes patients with persistent diabetic macular edema have higher hemoglobin A1c (HbA1C) levels. Bilateral disease is associated with more elevated HbA1C than unilateral disease.

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Diabetology

Background:

  • Diabetic macular edema (DME) is a leading cause of vision loss in diabetic patients.
  • Persistent clinically significant macular edema (CSME) poses a treatment challenge.
  • Glycemic control, measured by HbA1C, is crucial in managing diabetes and its complications.

Purpose of the Study:

  • To investigate the correlation between persistent diabetic macular edema and hemoglobin A1c (HbA1C) levels.
  • To compare HbA1C levels in patients with persistent versus resolved CSME.
  • To examine differences in HbA1C based on the laterality of CSME.

Main Methods:

  • Retrospective study analyzing patient records from January 2002 to January 2004.
  • Inclusion criteria: type 2 diabetes patients with persistent or resolved CSME despite prior treatment.

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  • HbA1C measurements obtained within three months of diagnosis were analyzed.

    • Main Results:

    • 92 patients (152 eyes) had persistent CSME, while 32 patients (56 eyes) had resolved CSME.
    • Mean HbA1C was significantly higher in patients with persistent CSME (8.9%) compared to resolved CSME (6.7%) (P = .0005).
    • 74% of patients with persistent CSME had HbA1C > 7.5%, versus 12.5% with resolved CSME. Bilateral CSME showed higher mean HbA1C (9.1%) than unilateral CSME (8.6%).

    Conclusions:

    • Elevated HbA1C levels are associated with persistent diabetic macular edema in type 2 diabetes.
    • Patients with persistent CSME demonstrate poorer glycemic control compared to those with resolved edema.
    • The severity of CSME, indicated by bilaterality, correlates with higher HbA1C levels.