Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacogenomics in admixed populations.

Guilherme Suarez-Kurtz1

  • 1Division of Pharmacology, Instituto Nacional de Câncer, Rio de Janeiro, RJ 22290-290, Brazil. kurtz@inca.gov.br

Trends in Pharmacological Sciences
|April 6, 2005
PubMed
Summary

Pharmacogenomics should focus on individual genetics, not ethnic groups, especially in admixed populations. This approach ensures equitable global health benefits and avoids a genomics divide.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DPYD polymorphisms in Native populations from the Brazilian Amazon: the absence of the variants in currently recommended clinical genotyping panels.

Pharmacogenetics and genomics·2026
Same author

Genotyping of DPYD and UGT1A1 in Brazilian oncological patients: applying pharmacogenomics in an admixed population.

Revista da Associacao Medica Brasileira (1992)·2026
Same author

Distribution of <i>NUDT15*4</i> in Native American populations of the Brazilian Amazon and risk of intolerance to thiopurine drugs.

Frontiers in pharmacology·2026
Same author

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update.

Clinical pharmacology and therapeutics·2026
Same author

Mutagenesis of the PALB2 WD40 domain identifies variants defective in interaction with BRCA2 and DNA repair.

The Journal of biological chemistry·2025
Same author

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels.

British journal of clinical pharmacology·2025

Area of Science:

  • Pharmacogenomics
  • Genetics
  • Population Health

Background:

  • Personalized drug therapy relies on pharmacogenomics, which studies genetic variations affecting drug response.
  • Admixed populations present unique challenges due to increased genetic diversity and fluid ethnic labels.
  • Current pharmacogenomic data extrapolation from defined ethnic groups to global populations is uncertain.

Purpose of the Study:

  • To examine the challenges and advantages of pharmacogenomics in admixed populations.
  • To advocate for a broader scope in pharmacogenomic research regarding target and population diversity.
  • To prevent a global genomics divide.

Main Methods:

  • Review of existing literature on pharmacogenomics in admixed populations.
  • Analysis of genetic individuality versus inter-ethnic differences in drug polymorphism frequencies.
  • Case examples from trihybrid populations in the Americas.

Main Results:

  • Genetic individuality is a more reliable basis for personalized medicine than broad ethnic classifications.
  • Admixed populations require tailored pharmacogenomic approaches due to complex genetic substructure.
  • Extrapolation of data from homogenous ethnic groups to diverse populations is scientifically unsound.

Conclusions:

  • Pharmacogenomics must prioritize individual genetic profiles over ethnic group generalizations for effective personalized medicine.
  • Research in admixed populations is crucial for advancing global pharmacogenomic applications and ensuring health equity.
  • Expanding research scope to include diverse populations is essential to realize the full potential of pharmacogenomics worldwide.

Related Experiment Videos