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Updated: Aug 18, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Changes in haemostasis during normal pregnancy
Ekaterina H Uchikova1, Ilija I Ledjev
1Department of Obstetrics and Gynecology, Higher Medical Institute, Plovdiv Bul.Konstantin, Velichkov 9, Plovdiv, Bulgaria. ekaterinauchikova@Yahoo.com.au
Objectives:
(1) To study the changes in the haemostatic variables during normal pregnancy, and (2) to compare them with the corresponding variables in a control group of nonpregnant women.
Setting:
University Hospital.
Subjects:
The study involves two groups of women: pregnant women (in 35th-40th gestational weeks (GW)) (N = 35) and a control group of nonpregnant women (N = 35).
Methods:
We examined the global tests, the variables relating to coagulation and fibrinolysis and the group of natural inhibitors of coagulation, and compared them between the two groups.
Results:
The pregnant women had statistically significantly higher values for: prothrombin time (PT) (P < 0.0001), thrombin time (TT) (P < 0.0001), fibrinogen (P < 0.0001), activity of factor VII (P < 0.0001), factor X (P < 0.0001) and alpha2-antiplasmin (P < 0.002), plasma concentration of D-dimer (plsDD) (P < 0.0001) and activity of heparin cofactor II (HCII) (P < 0.002). They had statistically significantly lower activity of protein C (PrC) (P < 0.0001) and of total protein S (TPrS) (P < 0.0001).
Conclusion:
During normal pregnancy the activation of coagulation is counterbalanced by the activation of fibrinolysis, which maintains the haemostatic balance.
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