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Published on: May 21, 2019
DNA photocleavage and biological activity of a pyrene dihydrodioxin
Eric T Mack1, Dagne Birzniece, Darren R Veach
1Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Bioorganic & Medicinal Chemistry Letters
|April 6, 2005
Abstract:
A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the phiX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.

