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Gene conversion and concerted evolution in bacterial genomes.

Gustavo Santoyo1, David Romero

  • 1Programa de Ingeniería Genómica, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Apartado Postal 565-A, Cuernavaca, Morelos, Mexico.

FEMS Microbiology Reviews
|April 6, 2005
PubMed
Summary

Gene conversion, the transfer of genetic information between homologous sequences, occurs in bacteria. This process impacts multigene families, mutation reversion, and antigenic variation in pathogens.

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Area of Science:

  • Microbiology
  • Genetics
  • Molecular Biology

Background:

  • Gene conversion is the non-reciprocal transfer of genetic information between homologous DNA sequences.
  • Demonstrating non-reciprocity in gene conversion presents methodological challenges.
  • Gene conversion is observed across diverse bacterial species.

Purpose of the Study:

  • To review examples of gene conversion in bacteria, including those identified through genomic studies.
  • To discuss molecular models explaining the mechanisms of gene conversion.
  • To explore the association between gene conversion and crossover events.

Main Methods:

  • Literature review of bacterial gene conversion studies.
  • Analysis of molecular models for gene conversion.

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  • Examination of gene conversion's role in bacterial evolution and pathogenesis.

    • Main Results:

    • Gene conversion contributes to the concerted evolution of bacterial multigene families.
    • It plays a significant role in high-frequency reversion of mutations in repeated genes.
    • Gene conversion is crucial for generating antigenic variation in bacterial pathogens, aiding immune evasion.

    Conclusions:

    • Gene conversion is a significant genetic mechanism in bacteria with broad implications.
    • It influences genome evolution, mutation dynamics, and host-pathogen interactions.
    • Understanding gene conversion mechanisms and their association with crossovers is vital.