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Related Experiment Videos

Low renin hypertensive states: perspectives, unsolved problems, future research.

Richard D Gordon1, John H Laragh, John W Funder

  • 1Endocrine Hypertension Research Centre, University of Queensland Department of Medicine at Princess Alexandra Hospital, Woolloongabba 4102, Queensland, Australia. richardgordon@uq.edu.au

Trends in Endocrinology and Metabolism: TEM
|April 6, 2005
PubMed
Summary

Primary aldosteronism, a genetic cause of hypertension, is treatable and potentially the most common curable form of high blood pressure. Early screening is recommended for all hypertensive patients to prevent complications.

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Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism.

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Who and How Should We Screen for Primary Aldosteronism?

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Recognising primary aldosteronism as a disorder in its own right.

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Primary Aldosteronism: Imaging vs. Lateralization.

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Primary Aldosteronism: Where Are We Now? Where to From Here?

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Primary Aldosteronism: Three Strikes and Out.

Hypertension (Dallas, Tex. : 1979)·2021

Area of Science:

  • Endocrinology
  • Genetics
  • Nephrology

Background:

  • Familial low renin hypertension has known genetic causes.
  • Primary aldosteronism, a specific type, is treatable via medication or surgery.
  • It presents with variable expression and long asymptomatic phases.

Purpose of the Study:

  • To highlight primary aldosteronism as a common, curable cause of hypertension.
  • To emphasize the role of aldosterone in hypertension and end-organ damage.
  • To advocate for screening of primary aldosteronism in hypertensive individuals.

Main Methods:

  • Review of genetic studies on familial hypertension.
  • Analysis of clinical data on primary aldosteronism prevalence and natural history.
  • Evaluation of evidence linking aldosterone to vascular inflammation and organ damage.

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Main Results:

  • Primary aldosteronism may be the most common curable cause of hypertension.
  • Inappropriate aldosterone levels contribute to hypertension, vascular inflammation, and organ damage.
  • Mineralocorticoid receptor blockade can prevent these adverse effects.

Conclusions:

  • Primary aldosteronism is a significant and treatable condition.
  • Screening for primary aldosteronism in hypertensive patients is warranted.
  • Targeting the mineralocorticoid receptor offers a therapeutic strategy.