A new function for the Elongator complex: polarization of Rab activity?

The Elongator complex was first identified through association with hyperphosphorylated forms of RNA polymerase II and was thought to have a role in transcriptional elongation in yeast. In this issue of Molecular Cell, Rahl et al. suggest a novel function for this complex: regulating polarized cell-surface transport. Defects in the human form of this complex result in a neurodegenerative disease, familial dysautomia (FD), suggesting that a deficiency in neuronal polarized trafficking is the underlying cause of FD.