Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microtubule tips redirect actin assembly.

Anthony Bretscher1

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

Developmental Cell
|April 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane in <i>S. cerevisiae</i>.

eLife·2022
Same author

Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.

G3 (Bethesda, Md.)·2022
Same author

The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells <sup>†</sup>.

Molecular biology of the cell·2021
Same author

Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain.

The Journal of cell biology·2021
Same author

Yeast Rgd3 is a phospho-regulated F-BAR-containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology.

Molecular biology of the cell·2020
Same author

Regulation of actin-based apical structures on epithelial cells.

Journal of cell science·2018
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

Researchers discovered a direct link between microtubule tip complexes and formin For3p in fission yeast. This connection regulates actin cable assembly, crucial for cell growth and switching from one to both cell ends.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cytoskeleton Dynamics

Background:

  • Microtubules are essential for cell structure and division.
  • Actin cables are critical for cell growth in fission yeast.
  • Regulation of actin cable assembly is key to cell polarity.

Purpose of the Study:

  • To elucidate the molecular mechanism linking microtubule dynamics to actin cable formation.
  • To identify the protein complex responsible for regulating actin assembly sites.
  • To understand how fission yeast switches actin assembly from one to both cell ends.

Main Methods:

  • Investigated protein interactions in fission yeast.
  • Utilized microscopy to observe microtubule and actin dynamics.
  • Focused on the role of the microtubule tip complex and formin For3p.

Related Experiment Videos

Main Results:

  • A direct molecular link was established between the microtubule tip complex and formin For3p.
  • This link mediates the switch in actin cable assembly sites.
  • The microtubule tip complex directly influences the nucleator of actin cables.

Conclusions:

  • The microtubule tip complex directly regulates formin For3p activity.
  • This regulation is essential for establishing bipolar actin cable assembly.
  • Provides a molecular basis for coordinating microtubule growth with cell polarity.