Related Experiment Videos
Tianeptine, a specific serotonin uptake enhancer, decreases ethanol intake in rats
M Daoust1, P Compagnon, E Legrand
1Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|January 1, 1992
Abstract:
The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function.