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Related Experiment Videos

Imprinting and assisted reproductive technology.

Eamonn R Maher1

  • 1Section of Medical and Molecular Genetics, Institute of Biomedical Research, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK. e.r.maher@bham.ac.uk

Human Molecular Genetics
|April 6, 2005
PubMed
Summary
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Assisted reproductive technology (ART) births are rising, but studies suggest a slight increase in birth defects and imprinting disorders in ART children. Further research is needed to understand the long-term health outcomes and epigenetic effects of ART procedures.

Area of Science:

  • Reproductive Medicine
  • Developmental Biology
  • Epigenetics

Background:

  • Assisted reproductive technology (ART) births have significantly increased globally.
  • While generally safe, ART is associated with a potential small excess of birth defects and low birth weight.
  • Emerging evidence suggests a possible link between ART and imprinting disorders like Beckwith-Wiedemann and Angelman syndromes.

Purpose of the Study:

  • To review the current evidence on potential health risks in children conceived via ART.
  • To investigate the association between ART procedures and imprinting disorders.
  • To highlight the need for further research into the long-term epigenetic consequences of ART.

Main Methods:

  • Review of recent clinical studies and animal research on ART outcomes.

Related Experiment Videos

  • Analysis of reported frequencies of birth defects and imprinting disorders in ART-conceived children.
  • Examination of epigenetic changes in imprinted genes following in vitro embryo culture.

    • Main Results:

    • ART-conceived children may have a small excess of birth defects and low birth weight.
    • Studies indicate a potential increased frequency of imprinting disorders in ART conceptions.
    • Animal studies support the hypothesis of disordered gene expression and epigenetic changes due to in vitro culture.

    Conclusions:

    • The absolute risk of imprinting disorders after ART appears very low, but requires further investigation.
    • The association between ART and imprinting disorders may be linked to embryo culture or shared mechanisms with infertility.
    • Further research is crucial to assess the long-term health outcomes and epigenetic effects of ART on children.