Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer epigenetics.

Peter W Laird1

  • 1Department of Surgery and Biochemistry and Molecular Biology, University of Southern California, 90086-9176, USA.

Human Molecular Genetics
|April 6, 2005
PubMed
Summary
This summary is machine-generated.

Cancer epigenetics is advancing with new therapies and diagnostic tools. DNA methylation patterns are key for classifying, detecting, and assessing cancer risk, improving patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide profiling of unmodified DNA using methyltransferase-directed tagging and enrichment.

Cell reports methods·2025
Same author

High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics.

Nature communications·2025
Same author

Pan-cancer immune and stromal deconvolution predicts clinical outcomes and mutation profiles.

Scientific reports·2025
Same author

Three-dimensional genome landscape of primary human cancers.

Nature genetics·2025
Same author

Protocol for obtaining cancer type and subtype predictions using subSCOPE.

STAR protocols·2025
Same author

Protocol for assessing distances in pathway space for classifier feature sets from machine learning methods.

STAR protocols·2025
Same journal

Utrophin requires α-Syntrophin to maintain neuromuscular junction integrity in mdx mice.

Human molecular genetics·2026
Same journal

A novel gene ACTRT3 mutations induce sperm malformations and fertilization failure via Acrosomal ultrastructural defects.

Human molecular genetics·2026
Same journal

Nucleic acid-based therapeutic strategies for modulator-refractory cystic fibrosis-causing variants.

Human molecular genetics·2026
Same journal

Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

Human molecular genetics·2026
Same journal

Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.

Human molecular genetics·2026
Same journal

Retraction: Aqua-soluble DDQ reduces the levels of Dr1 and Ab and inhibits abnormal interactions between Ab and Dr1 and protects Alzheimer's disease neurons from Ab- and Dr1-induced mitochondrial and synaptic toxicities.

Human molecular genetics·2026
See all related articles

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer epigenetics is rapidly evolving, integrating knowledge of chromatin structure, histone modification, transcriptional activity, and DNA methylation.
  • Epigenetic therapy is expanding to include combination treatments, such as histone deacetylase inhibitors and DNA methyltransferase inhibitors.

Purpose of the Study:

  • To highlight recent advances in cancer epigenetics, focusing on therapeutic strategies and diagnostic applications.
  • To discuss the role of DNA methylation in cancer classification, detection, and risk assessment.

Main Methods:

  • Review of current research in epigenetic therapy and diagnostic marker development.
  • Incorporation of technologies like microarrays, high-throughput bisulfite genomic sequencing, and mass spectrometry for epigenome analysis.

Related Experiment Videos

Main Results:

  • Zebularine, an oral DNA methyltransferase inhibitor, shows promise for epigenetic therapy.
  • Aberrant DNA methylation patterns are effective as classification, sensitive detection, and risk assessment markers.
  • Sensitive detection technologies are expanding beyond blood-based tests to diverse sample sources and risk assessment.

Conclusions:

  • Epigenetic therapy is becoming more sophisticated with combination treatments.
  • DNA methylation analysis offers powerful diagnostic and prognostic applications in oncology.
  • Technological advancements are enhancing the scope and utility of epigenetic markers in cancer management.