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Chronic progressive CNS histoplasmosis presenting in childhood: response to fluconazole therapy
I V Rivera1, R G Curless, F J Indacochea
1Department of Neurology, University of Miami School of Medicine, Florida.
Pediatric Neurology
|March 1, 1992
Abstract:
An 18-year-old Hispanic female developed symptoms of a Histoplasma capsulatum infection at 9 1/2 years of age. Initial problems of ataxia and hydrocephalus were followed by seizures and a cranial nerve palsy which developed over several years. T1-weighted cranial magnetic resonance imaging studies revealed numerous high-signal lesions; subsequently, signs of multisystem dissemination developed. Treatment included ventriculoperitoneal shunting, corticosteroids, amphotericin B, and a new antifungal agent, fluconazole, which was responsible for marked improvement.