Related Experiment Video

Updated: Aug 18, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

The relationship between the androgen receptor CAG repeat polymorphism length and the response to intermittent

L Klotz¹, A Correia, W Zhang

¹Division of Urology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Prostate Cancer and Prostatic Diseases

|April 6, 2005

Abstract

Objective:

To determine whether the duration of the off-treatment interval in patients being treated with intermittent androgen deprivation therapy can be predicted by the length of the CAG trinucleotide repeat polymorphism in the androgen receptor.

Methods:

This is a companion study to a prospective randomized trial, NCIC CTG PR-7, comparing intermittent to continuous androgen deprivation therapy in men with PSA progression after radiation therapy. The duration of the first off-treatment interval was established for 76 participants randomized to the intermittent therapy arm of the trial. Androgen receptor CAG repeat polymorphism lengths were determined for these 76 participants. Statistical analysis was completed to determine a relationship between CAG repeat length and the duration of the off-treatment interval.

Results:

A significant correlation was not established (P = 0.424) between androgen receptor CAG repeat length and the duration of the first off-treatment interval. Categorical analysis of CAG repeat lengths using 18 and 22 as cutoff points did not find any significant difference in the mean duration of the off-treatment interval between categories (P = 0.672 and 0.774, respectively).

Conclusion:

No relationship was established between the duration of the first off-treatment interval and the CAG repeat length.

More Related Videos

Serum and Plasma Copy Number Detection Using Real-time PCR

Serum and Plasma Copy Number Detection Using Real-time PCR

Published on: December 15, 2017

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...

Articles linked to this work by shared authors, journal, and citation graph.

Precision Measurement of the Muon Charge Asymmetry from W-Boson Decays in pp Collisions at sqrt[s]=13 TeV in the Forward Region.

Physical review letters·2026

Polarization Measurement of Λ_{c}^{+} and Λ[over ¯]_{c}^{-} Baryons in p-Ne Collisions at sqrt[s_{NN}]=68.6 GeV.

Physical review letters·2026

First Measurement of the Decay-Time-Integrated CP Asymmetry in B_{s}^{0}→D_{s}^{-}π^{+} Decays.

Physical review letters·2026

First Evidence of the Decay B^{+}→π^{+}e^{+}e^{-}.

Physical review letters·2026

Study of Nuclear Effects on Charm Production in Light-Ion Collisions.

Physical review letters·2026

CP Violation Analysis of Local and Nonlocal Amplitudes in the B[over ¯]^{0}→K[over ¯]^{*0}μ^{+}μ^{-} Decay.

Physical review letters·2026

See all related articles